Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
â€
Total Omega-3 Fatty Acids as TG
1055 mg
â€
EPA (Eicosapentaenoic Acid)
690 mg
â€
DHA (Docosahexaenoic Acid)
310 mg
â€
Other Omega-3 Fatty Acids
55 mg
â€
Top Medical Research Studies
8
We explored an innovative approach to treating glioblastoma, the most common malignant brain tumor, by utilizing docosahexaenoic acid (DHA) liposomes. These liposomes were created using a microfluidic system that allowed for fine-tuning various properties, which could enhance their effectiveness in targeting tumor cells.
Our findings revealed that these DHA liposomes, ranging in size from 80 nm to 130 nm, were successfully taken up by glioblastoma cells. This uptake was promising, as we saw a reduction in the viability of these cancerous cells. Interestingly, we also observed that DHA liposomes were significantly better at triggering cell death mechanisms compared to free DHA, specifically through pathways that involved caspase-3.
Overall, our study suggests that these microfluidic-derived DHA liposomes might offer new avenues for developing therapies using omega-3 fatty acids against brain tumors, potentially leading to more effective treatment options in the future.
Our findings revealed that these DHA liposomes, ranging in size from 80 nm to 130 nm, were successfully taken up by glioblastoma cells. This uptake was promising, as we saw a reduction in the viability of these cancerous cells. Interestingly, we also observed that DHA liposomes were significantly better at triggering cell death mechanisms compared to free DHA, specifically through pathways that involved caspase-3.
Overall, our study suggests that these microfluidic-derived DHA liposomes might offer new avenues for developing therapies using omega-3 fatty acids against brain tumors, potentially leading to more effective treatment options in the future.
Read More
8
We investigated how docosahexaenoic acid (DHA) impacts glioblastoma, a type of aggressive brain tumor notorious for its poor outcomes. The focus was on neural stem-like cells within these tumors, as they are known to contribute to drug resistance and promote the heterogeneity of the tumor.
Our research involved examining patient-derived glioblastoma neural stem-like cells grown in neurosphere cultures. We wanted to see how treatments with levels of DHA and arachidonic acid (AA) would affect the fatty acid profiles of these cells. Notably, we discovered that DHA treatment increased both the levels of DHA and the ratio of DHA to AA in these cells, with the assistance of brain fatty acid-binding protein (FABP7) which plays a crucial role in facilitating the uptake of DHA.
An interesting finding was that as the cells absorbed more DHA, their ability to migrate diminished. This could signal a potential therapeutic avenue where increasing DHA in glioblastoma could restrain the aggressive behavior of these neural stem-like cells, potentially leading to better outcomes for patients.
More research will be essential to fully understand the implications of this increased DHA content in the tumor microenvironment and its overall effects on the progression of glioblastoma.
Our research involved examining patient-derived glioblastoma neural stem-like cells grown in neurosphere cultures. We wanted to see how treatments with levels of DHA and arachidonic acid (AA) would affect the fatty acid profiles of these cells. Notably, we discovered that DHA treatment increased both the levels of DHA and the ratio of DHA to AA in these cells, with the assistance of brain fatty acid-binding protein (FABP7) which plays a crucial role in facilitating the uptake of DHA.
An interesting finding was that as the cells absorbed more DHA, their ability to migrate diminished. This could signal a potential therapeutic avenue where increasing DHA in glioblastoma could restrain the aggressive behavior of these neural stem-like cells, potentially leading to better outcomes for patients.
More research will be essential to fully understand the implications of this increased DHA content in the tumor microenvironment and its overall effects on the progression of glioblastoma.
Read More
8
We investigated the role of docosahexaenoic acid (DHA) in targeting glioblastoma, a challenging brain tumor with limited treatment options. By utilizing a special technique to create DHA liposomes, we aimed to reduce the inflammatory environment surrounding the tumor. This innovative approach allowed for a targeted delivery of DHA to the affected areas.
Through our research, we observed that these DHA liposomes were quickly taken up by macrophages, a type of immune cell, without causing any harm to them. We also discovered that these liposomes significantly lowered the activity of genes associated with inflammation and decreased the release of key inflammatory cytokines in both stimulated macrophages and glioblastoma cells.
Interestingly, while the DHA liposomes showed effectiveness in regulating inflammation, they did not notably change the expression of a certain anti-inflammatory gene in macrophages. Furthermore, our findings indicated that using DHA in liposome form was more effective than administering it freely.
Overall, our study highlights a promising strategy for using DHA liposomes to target glioblastoma and its inflammatory microenvironment. This innovative approach could lead to new treatment options for patients facing this aggressive type of brain cancer.
Through our research, we observed that these DHA liposomes were quickly taken up by macrophages, a type of immune cell, without causing any harm to them. We also discovered that these liposomes significantly lowered the activity of genes associated with inflammation and decreased the release of key inflammatory cytokines in both stimulated macrophages and glioblastoma cells.
Interestingly, while the DHA liposomes showed effectiveness in regulating inflammation, they did not notably change the expression of a certain anti-inflammatory gene in macrophages. Furthermore, our findings indicated that using DHA in liposome form was more effective than administering it freely.
Overall, our study highlights a promising strategy for using DHA liposomes to target glioblastoma and its inflammatory microenvironment. This innovative approach could lead to new treatment options for patients facing this aggressive type of brain cancer.
Read More
Most Useful Reviews
7.5
Stimulates brain development
722 people found this helpful
I find that omega-3s from cold water fish provide the best absorption. This supplement restores neurons, positively impacting brain function and development. While it can cause hyperactivity, the effects are generally very beneficial.
Read More
6
Improves brain function
730 people found this helpful
This is the best Omega-3 I've tried, made from cold water fish. It aids brain activity, reduces heart disease risk, and improves skin quality. My joints feel better, and I no longer have dry skin; I recommend it!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8
- All Researches
9
We investigated the effects of eicosapentaenoic acid (EPA) alongside docosahexaenoic acid (DHA) on medulloblastoma, a common and aggressive brain tumor in children.
In our study, we treated medulloblastoma cell lines with these omega-3 fatty acids and observed notable changes. Both EPA and DHA significantly reduced the production of prostaglandin E2, a compound associated with tumor growth and inflammation. Furthermore, we saw that these treatments impaired the viability of medulloblastoma cells, meaning fewer cancer cells were able to survive and grow. Additionally, the treatment led to increased cell death and reduced the ability of these cells to form colonies.
When we moved to the in vivo part of our study, where we implanted human medulloblastoma cells into mice, the results were promising. Mice treated with DHA, with or without EPA, experienced reduced tumor growth. Notably, levels of prostaglandin E and another compound, prostacyclin, dropped significantly in the tumors of treated animals compared to those that did not receive treatment. This suggests that the omega-3 fatty acids helped create a less favorable environment for tumor growth.
Our analysis uncovered that the treatment led to a downregulation of several key genes, with CRYAB being the most significantly affected. We confirmed this finding via various techniques, including immunohistochemistry. This research hints at the potential of combining DHA and EPA in existing treatment plans to target inflammation specific to the tumor environment.
In our study, we treated medulloblastoma cell lines with these omega-3 fatty acids and observed notable changes. Both EPA and DHA significantly reduced the production of prostaglandin E2, a compound associated with tumor growth and inflammation. Furthermore, we saw that these treatments impaired the viability of medulloblastoma cells, meaning fewer cancer cells were able to survive and grow. Additionally, the treatment led to increased cell death and reduced the ability of these cells to form colonies.
When we moved to the in vivo part of our study, where we implanted human medulloblastoma cells into mice, the results were promising. Mice treated with DHA, with or without EPA, experienced reduced tumor growth. Notably, levels of prostaglandin E and another compound, prostacyclin, dropped significantly in the tumors of treated animals compared to those that did not receive treatment. This suggests that the omega-3 fatty acids helped create a less favorable environment for tumor growth.
Our analysis uncovered that the treatment led to a downregulation of several key genes, with CRYAB being the most significantly affected. We confirmed this finding via various techniques, including immunohistochemistry. This research hints at the potential of combining DHA and EPA in existing treatment plans to target inflammation specific to the tumor environment.
Read More
9
We investigated the potential of docosahexaenoic acid (DHA) as part of a novel treatment for glioblastoma, a challenging brain tumor. Our study involved formulating mebendazole (MBZ) microemulsions that included DHA along with other compounds, assessing their effectiveness in an orthotopic C6 rat model.
The formulations were carefully characterized before testing. We found that one formulation—composed of oleic acid and labrafil, with a 0.1% mucoadhesive agent—showed promising results. Importantly, there were no observable toxic effects on the nasal epithelium, suggesting the safety of this delivery method.
Furthermore, we observed improved survival rates in the treated rats compared to the control group. Our findings implied that this combined approach with DHA and MBZ microemulsions might offer a new avenue for glioblastoma treatment, although we noted that the contribution of DHA alone couldn't be fully isolated.
Overall, our research encourages the exploration of innovative strategies to enhance the treatment of malignant brain tumors through targeted intranasal delivery.
The formulations were carefully characterized before testing. We found that one formulation—composed of oleic acid and labrafil, with a 0.1% mucoadhesive agent—showed promising results. Importantly, there were no observable toxic effects on the nasal epithelium, suggesting the safety of this delivery method.
Furthermore, we observed improved survival rates in the treated rats compared to the control group. Our findings implied that this combined approach with DHA and MBZ microemulsions might offer a new avenue for glioblastoma treatment, although we noted that the contribution of DHA alone couldn't be fully isolated.
Overall, our research encourages the exploration of innovative strategies to enhance the treatment of malignant brain tumors through targeted intranasal delivery.
Read More
8
We explored the potential of eicosapentaenoic acid (EPA) in combination with cisplatin (CiSP) as a treatment for brain tumors, specifically glioblastoma cells. Our study involved comparing the effects of different treatments on brain tumor cells, including a control group, EPA treatment, CiSP treatment, and a combination of both.
Our findings indicated that when CiSP was applied, there was a significant increase in calcium responses in the tumor cells, which was crucial for triggering cell death. EPA, known for its oxidant properties due to its high polyunsaturated fatty acid content, further enhanced these responses, leading to increased mitochondrial stress and higher levels of reactive oxygen species.
Not only did EPA boost the effects of CiSP, but it also contributed to increased lipid peroxidation and apoptosis in the tumor cells. These results point out that when we use EPA alongside CiSP, the combined treatment appears to increase the therapeutic effects, making the cancer cells more susceptible to the treatment.
However, we must acknowledge that while the combination treatment showed promise, further research would be necessary to isolate the effects of EPA alone and to confirm its effectiveness in clinical settings. Nonetheless, our study suggests that activating the TRPM2 channel with EPA could be a valuable strategy in treating glioblastoma with Cisplatin.
Our findings indicated that when CiSP was applied, there was a significant increase in calcium responses in the tumor cells, which was crucial for triggering cell death. EPA, known for its oxidant properties due to its high polyunsaturated fatty acid content, further enhanced these responses, leading to increased mitochondrial stress and higher levels of reactive oxygen species.
Not only did EPA boost the effects of CiSP, but it also contributed to increased lipid peroxidation and apoptosis in the tumor cells. These results point out that when we use EPA alongside CiSP, the combined treatment appears to increase the therapeutic effects, making the cancer cells more susceptible to the treatment.
However, we must acknowledge that while the combination treatment showed promise, further research would be necessary to isolate the effects of EPA alone and to confirm its effectiveness in clinical settings. Nonetheless, our study suggests that activating the TRPM2 channel with EPA could be a valuable strategy in treating glioblastoma with Cisplatin.
Read More
8
Our exploration focused on how eicosapentaenoic acid (EPA) impacts glioblastoma, the most aggressive type of brain tumor. To delve into this, we treated U87 glioma cells with three types of fatty acids: palmitic acid, oleic acid, and EPA. We used a specialized microscope to track how these fatty acids were absorbed by the cells and how they contributed to the formation of lipid droplets.
Interestingly, we found that supplying 200 µM of these fatty acids led to significant accumulation of lipid droplets in the glioma cells. By inhibiting the synthesis of triglycerides, we noticed a depletion of these droplets, which resulted in heightened lipotoxicity. This was marked by a notable reduction in cell proliferation rates.
Most strikingly, when we combined EPA treatment with the depletion of lipid droplets, we observed that it significantly lowered the survival rate of the glioma cells by over 50%. This stark result underscores the potential therapeutic capabilities of this approach. As we look to the future, we are committed to uncovering the metabolic mechanisms behind EPA-induced lipotoxicity, with the aim of enhancing its effects against cancer.
Interestingly, we found that supplying 200 µM of these fatty acids led to significant accumulation of lipid droplets in the glioma cells. By inhibiting the synthesis of triglycerides, we noticed a depletion of these droplets, which resulted in heightened lipotoxicity. This was marked by a notable reduction in cell proliferation rates.
Most strikingly, when we combined EPA treatment with the depletion of lipid droplets, we observed that it significantly lowered the survival rate of the glioma cells by over 50%. This stark result underscores the potential therapeutic capabilities of this approach. As we look to the future, we are committed to uncovering the metabolic mechanisms behind EPA-induced lipotoxicity, with the aim of enhancing its effects against cancer.
Read More
8
We sought to understand how eicosapentaenoic acid (EPA), a type of highly unsaturated fatty acid, influences brain tumors, specifically gliomas. Using various glioma models, including human samples and a rat model, we looked at how EPA could trigger tumor regression and promote cell death, known as apoptosis.
Our findings revealed that when glioma cells were exposed to EPA, significant reductions in tumor size and increased apoptosis were observed. Furthermore, we noted that EPA worked well in conjunction with gamma radiation, enhancing the effects of this common treatment.
Interestingly, our observations indicated that EPA preserved the surrounding healthy brain tissue and blood vessels, which is a significant consideration in treating brain tumors. We also found minimal inflammation in tumors treated with EPA, suggesting a more favorable safety profile compared to conventional treatments. Overall, the results indicate that EPA could be a promising addition to glioma therapies.
Our findings revealed that when glioma cells were exposed to EPA, significant reductions in tumor size and increased apoptosis were observed. Furthermore, we noted that EPA worked well in conjunction with gamma radiation, enhancing the effects of this common treatment.
Interestingly, our observations indicated that EPA preserved the surrounding healthy brain tissue and blood vessels, which is a significant consideration in treating brain tumors. We also found minimal inflammation in tumors treated with EPA, suggesting a more favorable safety profile compared to conventional treatments. Overall, the results indicate that EPA could be a promising addition to glioma therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Stimulates brain development
722 people found this helpful
I find that omega-3s from cold water fish provide the best absorption. This supplement restores neurons, positively impacting brain function and development. While it can cause hyperactivity, the effects are generally very beneficial.
Read More
6
Improves brain function
730 people found this helpful
This is the best Omega-3 I've tried, made from cold water fish. It aids brain activity, reduces heart disease risk, and improves skin quality. My joints feel better, and I no longer have dry skin; I recommend it!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Öcal Ö, Nazıroğlu M. Eicosapentaenoic acid enhanced apoptotic and oxidant effects of cisplatin via activation of TRPM2 channel in brain tumor cells. Chem Biol Interact. 2022;359:109914. doi:10.1016/j.cbi.2022.109914
- Ljungblad L, Bergqvist F, Tümmler C, Madawala S, Olsen TK, et al. Omega-3 fatty acids decrease CRYAB, production of oncogenic prostaglandin E and suppress tumor growth in medulloblastoma. Life Sci. 2022;295:120394. doi:10.1016/j.lfs.2022.120394
- Yuan Y, Shah N, Almohaisin MI, Saha S, Lu F. Assessing fatty acid-induced lipotoxicity and its therapeutic potential in glioblastoma using stimulated Raman microscopy. Sci Rep. 2021;11:7422. doi:10.1038/s41598-021-86789-9
- Denkins Y, Kempf D, Ferniz M, Nileshwar S, Marchetti D. Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma. J Lipid Res. 2005;46:1278.
- Salvati S, Natali F, Attorri L, Raggi C, Di Biase A, et al. Stimulation of myelin proteolipid protein gene expression by eicosapentaenoic acid in C6 glioma cells. Neurochem Int. 2004;44:331.
- Leaver HA, Bell HS, Rizzo MT, Ironside JW, Gregor A, et al. Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma. Prostaglandins Leukot Essent Fatty Acids. 2002;66:19.
- Mendanha D, Casanova MR, Gimondi S, Ferreira H, Neves NM. Microfluidic-Derived Docosahexaenoic Acid Liposomes for Targeting Glioblastoma and Its Inflammatory Microenvironment. ACS Appl Mater Interfaces. 2024;16:40543. doi:10.1021/acsami.4c01368
- Mendanha D, Gimondi S, Costa BM, Ferreira H, Neves NM. Microfluidic-derived docosahexaenoic acid liposomes for glioblastoma therapy. Nanomedicine. 2023;53:102704. doi:10.1016/j.nano.2023.102704
- Choi WS, Xu X, Goruk S, Wang Y, Patel S, et al. FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells. Nutrients. 2021;13. doi:10.3390/nu13082664
- Xu X, Wang Y, Choi WS, Sun X, Godbout R. Super resolution microscopy reveals DHA-dependent alterations in glioblastoma membrane remodelling and cell migration. Nanoscale. 2021;13:9706. doi:10.1039/d1nr02128a
- Mena-Hernández J, Jung-Cook H, Llaguno-Munive M, GarcÃa-López P, Ganem-Rondero A, et al. Preparation and Evaluation of Mebendazole Microemulsion for Intranasal Delivery: an Alternative Approach for Glioblastoma Treatment. AAPS PharmSciTech. 2020;21:264. doi:10.1208/s12249-020-01805-x
- Tan X, Zou L, Qin J, Xia D, Zhou Y, et al. SQSTM1/p62 is involved in docosahexaenoic acid-induced cellular autophagy in glioblastoma cell lines. In Vitro Cell Dev Biol Anim. 2019;55:703. doi:10.1007/s11626-019-00387-8
